EX VIVO SUSCEPTIBILITIES OF PLASMODIUM VIVAX ISOLATES FROM THE CHINA-MYANMAR BORDER TO ANTIMALARIAL DRUGS AND ASSOCIATION WITH POLYMORPHISMS IN PVMDR1 AND PVCRT-O GENES.

Ex vivo susceptibilities of Plasmodium vivax isolates from the China-Myanmar border to antimalarial drugs and association with polymorphisms in Pvmdr1 and Pvcrt-o genes.

BackgroundVivax malaria is an important public health problem in the Greater Mekong Subregion (GMS), including the China-Myanmar border.Previous studies have found that Plasmodium vivax has decreased sensitivity to antimalarial drugs in some areas of the GMS, but the sensitivity of P.vivax to antimalarial drugs is unclear in the China-Myanmar borde

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Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner.

Endoplasmic reticulum (ER) stress is a common factor in the pathophysiology of diverse human diseases that are characterised by contrasting cellular behaviours, from proliferation in cancer to apoptosis in neurodegenerative disorders.Coincidently, dysregulation of AKT/PKB activity, which is the central regulator of cell growth, proliferation and su

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